Valder R Arruda Selected Research

Factor IX (Coagulation Factor IX)

2/2021	Inhibitors-Recent insights.
1/2021	Evolutionary insights into coagulation factor IX Padua and other high-specific-activity variants.
3/2019	Protein-Engineered Coagulation Factors for Hemophilia Gene Therapy.
10/2018	Padua FIXa resistance to Protein S and a potential therapy for hyperactive FIXa.
12/2017	Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.
3/2015	Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogs.
1/2015	Obstacles and future of gene therapy for hemophilia.
7/2010	Safety of AAV factor IX peripheral transvenular gene delivery to muscle in hemophilia B dogs.
6/2010	Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B.
10/2009	X-linked thrombophilia with a mutant factor IX (factor IX Padua).

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Valder R Arruda Research Topics

Disease

27	Hemophilia A (Haemophilia) 01/2022 - 04/2004
20	Hemophilia B (Haemophilia B) 02/2021 - 04/2002
14	Hemorrhage 01/2022 - 04/2003
3	Neoplasms (Cancer) 04/2012 - 01/2009
2	Thrombosis (Thrombus) 10/2018 - 10/2011
2	Liver Diseases (Liver Disease) 09/2018 - 06/2010
2	Vascular System Injuries 05/2013 - 10/2011
2	Ischemia 05/2009 - 07/2006
1	Immune System Diseases (Immune Disorders) 01/2021
1	Hepatitis 09/2018
1	Body Weight (Weight, Body) 12/2017
1	Infections 01/2013
1	Neoplasm Metastasis (Metastasis) 04/2012
1	Thrombophilia 10/2009
1	Factor VII Deficiency (Hypoproconvertinemia) 01/2009
1	von Willebrand Diseases (von Willebrand's Disease) 01/2009
1	Retinal Perforations 05/2008
1	Autoimmune Diseases (Autoimmune Disease) 10/2007
1	Thrombocytopenia (Thrombopenia) 01/2007
1	Atherosclerotic Plaque (Atheroma) 10/2004
1	Sickle Cell Anemia (Hemoglobin S Disease) 09/2004
1	Erectile Dysfunction 09/2004
1	Stuttering (Stammering) 09/2004
1	Acute Chest Syndrome 09/2004
1	Priapism 09/2004
1	Coronary Disease (Coronary Heart Disease) 08/2004
1	Myocardial Infarction 08/2004
1	Inborn Genetic Diseases (Disease, Hereditary) 05/2003

Drug/Important Bio-Agent (IBA)

20	Factor IX (Coagulation Factor IX)FDA LinkGeneric 02/2021 - 04/2002
16	Factor VIII (Coagulation Factor VIII)IBA 01/2022 - 04/2004
9	AntibodiesIBA 01/2022 - 01/2007
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2009
6	Blood Coagulation Factors (Coagulation Factor)IBA 01/2022 - 05/2012
4	factor IX-PaduaIBA 03/2021 - 10/2009
2	Recombinant ProteinsIBA 01/2020 - 10/2016
2	Neutralizing AntibodiesIBA 09/2018 - 12/2010
2	Biological ProductsIBA 10/2016 - 01/2015
2	7,7'- dimethoxy- (4,4'- bi- 1,3- benzodioxole)- 5,5'- dicarboxylic acid dimethyl ester (BDD)IBA 10/2016 - 11/2009
2	AnticoagulantsIBA 04/2012 - 07/2006
2	Enzyme Precursors (Zymogens)IBA 04/2012 - 10/2011
2	DNA (Deoxyribonucleic Acid)IBA 03/2011 - 05/2009
2	Thrombin FDA Link 07/2006 - 01/2006
2	Platelet Membrane GlycoproteinsIBA 10/2004 - 08/2004
2	Factor VII (Proconvertin)IBA 04/2004 - 04/2003
1	AutoantibodiesIBA 01/2022
1	B-domain-deleted factor VIIIIBA 03/2021
1	CytokinesIBA 01/2021
1	B-Cell Activating FactorIBA 01/2021
1	Transaminases (Aminotransferases)IBA 09/2018
1	CoagulantsIBA 12/2017
1	prothrombin complex concentrates (PPSB)IBA 12/2017
1	FurinIBA 10/2016
1	Peptide Elongation Factor 1 (EF-1)IBA 06/2014
1	AntigensIBA 06/2014
1	Immunoglobulins (Immunoglobulin)IBA 06/2014
1	Antigen-Antibody Complex (Immune Complex)IBA 06/2014
1	EpitopesIBA 01/2013
1	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 04/2012
1	Protein CIBA 04/2012
1	Peptide Hydrolases (Proteases)FDA Link 10/2011
1	PF-05230907IBA 10/2011
1	Hemostatics (Antihemorrhagics)IBA 10/2011
1	Factor Xa (Coagulation Factor Xa)IBA 10/2011
1	Phosphates (Orthophosphate)IBA 03/2011
1	CytosineIBA 03/2011
1	GuanosineIBA 03/2011
1	Complementary DNA (cDNA)IBA 03/2011
1	ferric chlorideIBA 12/2010
1	Arginine (L-Arginine)FDA Link 10/2009
1	Leucine (L-Leucine)FDA Link 10/2009
1	Becaplermin (PDGF-BB)FDA Link 05/2009
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 05/2009
1	Bile Acids and Salts (Bile Acids)IBA 01/2009
1	Retinaldehyde (Retinal)IBA 05/2008
1	AutoantigensIBA 10/2007
1	Warfarin (Coumadin)FDA LinkGeneric 07/2006
1	Enoxaparin (Lovenox)FDA LinkGeneric 07/2006
1	HirudinsIBA 07/2006
1	factor V LeidenIBA 01/2006
1	Hydroxyurea (Hydrea)FDA LinkGeneric 09/2004
1	Human Platelet AntigensIBA 08/2004
1	Factor VIIa (Activated Factor VII)IBA 04/2004
1	N-acetyltalosaminuronic acid (NAT)IBA 07/2002
1	A-factor (Streptomyces)IBA 04/2002

Therapy/Procedure

16	Therapeutics 01/2022 - 05/2003
3	Intramuscular Injections 03/2005 - 07/2002
1	Lasers (Laser) 12/2010
1	Operative Surgical Procedures 05/2009